Frequently Asked Questions

Frequently Asked Questions

Considering RYBELSUS®

There are many reasons that RYBELSUS® could be right for you. First and foremost, RYBELSUS®, along with diet and exercise, may help lower A1C. So, if you’re an adult whose A1C is no longer at goal, you should consider discussing a change in treatment with your healthcare provider.

Ask your healthcare provider if RYBELSUS® is right for you. Download a discussion guide to help get the conversation started.

RYBELSUS®, the first and only GLP-1 pill, is a prescription medicine taken once daily that, along with diet and exercise, may help lower blood sugar and A1C in adults with type 2 diabetes.

In a 6-month study, the majority of people taking RYBELSUS® reached an A1C of less than 7%.

Results are from a 6-month medical study with 703 adults with type 2 diabetes that compared 7 mg RYBELSUS® and 14 mg RYBELSUS® with a sugar pill when both were added to diet and exercise. People who took a sugar pill had a 0.3% lowering of A1C, and 31% reached an A1C goal of <7%.

In a 6-month study, the majority of people taking RYBELSUS® reached an A1C of less than 7%.


Results are from a 6-month medical study with 703 adults with type 2 diabetes that compared 7 mg RYBELSUS® and 14 mg RYBELSUS® with a sugar pill when both were added to diet and exercise. People who took a sugar pill had a 0.3% lowering of A1C, and 31% reached an A1C goal of <7%.

While not for weight loss, RYBELSUS® may help you lose some weight.

Yes. In a study, RYBELSUS® did not increase the risk of major cardiovascular (CV) events such as heart attack, stroke, or death.

In a cardiovascular safety study, 3183 adults with type 2 diabetes and a high risk of CV events were treated once daily with either 14 mg RYBELSUS® or a sugar pill in addition to their usual diabetes and CV medications.

RYBELSUS® works like your body’s naturally occurring GLP-1 to lower blood sugar in the following 3 ways:

1. Stimulates your pancreas to release more insulin when your blood sugar is high

2. Prevents your liver from making and releasing too much sugar

3. Slows down food leaving your stomach after eating

GLP-1, or glucagon-like peptide-1, is a natural hormone that helps your body keep blood sugar in balance. GLP-1 treatments work like this naturally occurring hormone. Until FDA approval of RYBELSUS®, GLP-1 treatments had only been available in an injectable form. RYBELSUS® is the first and only GLP-1 in a pill.

The RYBELSUS® Doctor Discussion Guide can help guide you through a conversation with your healthcare provider about whether RYBELSUS® is right for you.

Savings & Support

You can look up your co-pay and see how much RYBELSUS® will cost you.

aCommercially insured patients only. Eligibility and other restrictions apply.

bMessage and data rates may apply. Check with your mobile service provider. Message frequency will be based on your selections. Text HELP to 21848 for help. Text STOP to 21848 to quit. See Terms and Conditions of Use.

Yes! If eligible, you may pay as little as $10 for a 30-day prescription.a

There are 3 ways to get this Savings Offer:

Textb READY to 21848 to get co-pay savings.

Textb READY to 21848 to get co-pay savings.

You can also download a Savings Card online.

You can also download a Savings Card online.

Call 1-833-ASK-A-CDE and ask for assistance with the Savings Offer.
Monday – Friday, 9:00 am – 6:00 pm ET

Call 1-833-ASK-A-CDE and ask for assistance with the Savings Offer.

Monday – Friday, 9:00 am – 6:00 pm ET

aCommercially insured patients only. Eligibility and other restrictions apply.

bMessage and data rates may apply. Check with your mobile service provider. Message frequency will be based on your selections. Text HELP to 21848 for help. Text STOP to 21848 to quit. See Terms and Conditions of Use.

Texta READY to 21848 to get support through text messages with RYBELSUS® Connect.

Texta READY to 21848 to get support through text messages with RYBELSUS® Connect.

aMessage and data rates may apply. Check with your mobile service provider. Message frequency will be based on your selections. Text HELP to 21848 for help. Text STOP to 21848 to quit. See Terms and Conditions of Use.

Get medicine reminders

Receive helpful information

Receive motivational messages

Call a Certified Diabetes Educator


Give us a call for one-on-one, live support from a Certified Diabetes Educator (CDE)—and to learn more about taking RYBELSUS®.

Call 1-833-ASK-A-CDE (1-833-275-2233)
Monday – Friday, 9:00 am – 6:00 pm ET

Give us a call for one-on-one, live support from a Certified Diabetes Educator (CDE)—and to learn more about taking RYBELSUS®.

Call 1-833-ASK-A-CDE (1-833-275-2233)
Monday – Friday, 9:00 am6:00 pm ET

You can speak with a Certified Diabetes Educator by calling 1-833-ASK-A-CDE (1-833-275-2233). The Certified Diabetes Educator will be happy to answer your questions about RYBELSUS®.

Taking RYBELSUS®

For RYBELSUS® to work as planned to lower blood sugar, store RYBELSUS® in a dry place away from moisture and keep tablets in the original blister pack until you are ready to take one.

aSolo para pacientes con seguro de salud comercial. Se aplican requisitos de elegibilidad y otras restricciones.

bSe aplican tarifas por datos y mensajes. Consulte con su proveedor de servicios móviles. La frecuencia de los mensajes se basará en las opciones que usted haya seleccionado. Escriba AYUDA al 21848 para obtener ayuda. Escriba CANCELAR al 21848 para cancelar. Vea los Términos de uso y Condiciones.

Take on an empty stomach when you first wake up.

Take with no more than 4 ounces of plain water.

Wait at least 30 minutes before eating, drinking, or taking other oral medications.

RYBELSUS® works best if you eat 30 to 60 minutes after taking it.

If you miss a dose, the missed dose should be skipped, and the next dose should be taken the following day.

No, RYBELSUS® should be taken on an empty stomach when you first wake up.

Wait at least 30 minutes after taking RYBELSUS® before eating, drinking, or taking other oral medications. RYBELSUS® works best if you eat 30 to 60 minutes after taking RYBELSUS®.

Dosing and timing of your other medications may need to be adjusted.

You should talk with your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

In order for RYBELSUS® to be properly absorbed into the body, the RYBELSUS® tablet needs to rest on the stomach lining undisturbed for at least 30 minutes.

RYBELSUS® may not work as planned to lower blood sugar if it’s not taken as directed every day. Talk with your healthcare provider if you have any questions about taking RYBELSUS®.

When taken as instructed every day, RYBELSUS®, along with diet and exercise, may help improve your blood sugar. While taking RYBELSUS®, you may experience some side effects.

The most common side effects of RYBELSUS® may include nausea, stomach (abdominal) pain, diarrhea, decreased appetite, vomiting, and constipation. Make sure to talk with your healthcare provider if you have any questions about side effects.

Speak with your healthcare provider if you experience nausea or have any questions about side effects.

Here are some general nausea tips that may be helpful:

  • Slowly eat smaller, more frequent meals
  • Eat foods that are light and bland, like saltine crackers or plain bread
  • Avoid fried, greasy, or sweet foods
  • Drink clear or ice-cold drinks

It is not known if RYBELSUS® will harm your unborn baby. Women should stop taking RYBELSUS® 2 months before they plan to become pregnant. Talk to your healthcare provider about the best way to control your blood sugar if you plan to become pregnant or while you are pregnant.

Please contact your healthcare provider if you are pregnant or intend to become pregnant, or if you are breastfeeding or plan to breastfeed, while taking RYBELSUS®.

It is not known if RYBELSUS® passes into breast milk. Breastfeeding is not recommended during treatment with RYBELSUS®. You should talk to your healthcare provider about the best way to control your blood sugar while you are breastfeeding.

Please contact your healthcare provider if you are breastfeeding or plan to breastfeed.

The beginning dose is 3 mg for the first 30 days to help your body get used to the medicine.

Your healthcare provider will then prescribe a 7 mg dose to help lower blood sugar.

If more blood sugar control is needed after at least 30 days on the 7 mg dose, your healthcare provider may prescribe the 14 mg dose.

Store RYBELSUS® at room temperature 68°F–77°F in a dry place away from moisture. Many people taking pills use a pillbox to store their medicine. With RYBELSUS®, it's very important to keep your RYBELSUS® tablets in the blister pack until you are ready to take one. Removing tablets, or changing their form before you are ready to take them, can reduce how well RYBELSUS® works.

RYBELSUS® comes in a cardboard box or carton, which lists the name RYBELSUS® and the dosage, which can be 3 mg, 7 mg, or 14 mg. Each carton contains 3 blister packs with 10 tablets each. The carton also has a child-safety tab that must be pressed in order to access the blister packs.

3 mg dose

3 mg dose

7 mg dose

7 mg dose

14 mg dose

14 mg dose

RYBELSUS® comes in child-resistant packaging. To open the blister pack, press the tab labeled #1 with your thumb. While holding down #1, hold tab #2 with your other thumb and your pointer finger, then slide out the blister pack.

Keep tablet in the blister pack until you are ready to take it.

Push tablet out of blister. Do not cut from the packaging.

Swallow tablet whole. Do not cut, crush, or chew.


Store at room temperature 68°F–77°F (20°C–25°C).

Store in a dry place away from moisture.

Active ingredient: semaglutide (pronounced sem-a-gloo-tide)

Inactive ingredients:

  • magnesium stearate (pronounced mag-nee-zee-uhm stee-uh-reyt)
  • microcrystalline cellulose (pronounced my-kroh-kris-tl-in sel-yuh-lohs)
  • povidone (pronounced po-vi-done)
  • salcaprozate sodium (pronounced sal-kap-roe-zate sow-dee-uhm)

Everyone has a different wake-up routine. Here's a tip to help you remember to take RYBELSUS® when you first wake up: Keep your RYBELSUS® package and a small glass of plain water on your nightstand.

When you wake up, take your medicine with a sip of plain water (no more than 4 ounces), and then wait at least 30 minutes before eating, drinking, or taking any other oral medications. After 30 minutes, you can eat, drink, or take other oral medications, vitamins, or supplements. RYBELSUS® works best if you eat 30 to 60 minutes after taking it.

Wake up to lower A1C with RYBELSUS®

Once-daily RYBELSUS® is proven to significantly lower A1C.
 

Pay as little as $10 for a 30-day RYBELSUS® prescriptiona

Check your insurance coverage and learn about ways to save.

aCommercially insured patients only. Eligibility and other restrictions apply.

Support to help you start and stay on RYBELSUS®

RYBELSUS® Connect offers support when and where you need it. Textb READY to 21848 to get started.

aCommercially insured patients only. Eligibility and other restrictions apply.

bMessage and data rates may apply. Check with your mobile service provider. Message frequency will be based on your selections. Text HELP to 21848 for help. Text STOP to 21848 to quit. See Terms and Conditions of Use.