Once-Daily RYBELSUS® (semaglutide) tablets 7 mg or 14 mg Once-Daily RYBELSUS® (semaglutide) tablets 7 mg or 14 mg
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What to Expect With RYBELSUS®

For RYBELSUS® to work as planned, take it as directed, every day

Improving your blood sugar is a very important part of managing your type 2 diabetes. RYBELSUS®, along with healthy eating and staying active, may help.

You'll start with a 3 mg dose of RYBELSUS® for 30 days. Your healthcare provider will prescribe a 7 mg dose to take after the first 30 days.

Welcome to RYBELSUS® video thumbnail

Learn more about dose changes, side effects, and support while taking RYBELSUS®.

Learn more about dose changes, side effects, and support while taking RYBELSUS®.

START ON 3 mg

RYBELSUS® (semaglutide) 3mg bottle

The beginning dose is 3 mg for the first 30 days. This will give your body a chance to get used to the medicine.

STAY ON 7 mg

RYBELSUS® (semaglutide) 7mg bottle

When you finish all of the 3 mg pills, start your 7 mg prescription.

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Remember to pick up your 7 mg prescription from your pharmacy.

Why does my RYBELSUS® dose change?

  • The beginning dose is 3 mg for the first 30 days to help your body get used to the medicine
  • Your healthcare provider prescribed a 7 mg dose to help lower blood sugar
  • If more blood sugar control is needed after at least 30 days on the 7 mg dose, your healthcare provider may prescribe the 14 mg dose

Common side effects of RYBELSUS®

There are possible side effects when taking RYBELSUS®. Always talk to your healthcare provider right away about any side effect that bothers you or doesn't go away.

The most common side effects of RYBELSUS® may include:

Nausea

Stomach (abdominal) pain

Diarrhea

Decreased appetite

Vomiting

Constipation

Nausea

Decreased appetite

Stomach (abdominal) pain

Vomiting

Diarrhea

Constipation

Nausea, vomiting, and diarrhea are most common when first starting RYBELSUS® and when your dose increases.a

aIn studies, gastrointestinal side effects were more common in people taking RYBELSUS® than in people taking placebo, and people taking RYBELSUS® were more likely to stop treatment because of these side effects. Nausea, vomiting, and diarrhea may cause a loss of fluids (dehydration), which could cause existing kidney problems to get worse (including kidney failure).

If you experience any side effects while taking RYBELSUS®, please talk to your healthcare provider.

For a complete list of possible side effects of RYBELSUS®, see the Prescribing Information and Medication Guide.

For medical advice about side effects, talk with your healthcare provider. You may report side effects to the FDA at 1-800-FDA-1088.

Here are some general nausea tips that may be helpful:

Bread and a bowl of rice

Eat bland, low-fat foods, like crackers, toast, and rice

Steaming bowl of soup

Eat foods that contain water, like soups and gelatin

Burger crossed out

Avoid fried, greasy, or sweet foods

Person standing

Avoid lying down after you eat

Trees and a sun

Go outdoors for fresh air

Fork, spoon, and clock

Eat more slowly

Drink with ice

Drink clear or ice-cold drinks

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Textb READY to 21848 to sign up for support

RYBELSUS® Connect can help you establish a routine with text message reminders and motivational messages.

bMessage and data rates may apply. Check with your mobile service provider. Message frequency will be based on your selections. Text HELP to 21848 for help. Text STOP to 21848 to quit. See Terms and Conditions of Use.

GET STARTED
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Diabetes support when you need it

For one-on-one, live support from a Diabetes Health Coach, if you need it.

Call 1-833-ASK-A-CDE

(1-833-275-2233)

Monday – Friday, 9:00 AM – 6:00 Pm ET

CALL NOW
NEXT: Savings & Support
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Get your A1C DOWN with RYBELSUS®

Once-daily RYBELSUS® is proven to significantly lower A1C.

LEARN MORE
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Pay as little as $10 for up to a 3‑month RYBELSUS® prescriptiona

Check your insurance coverage and learn about ways to save.

START SAVING

aEligible, commercially insured patients only. For 3 mg dose, pay as little as $10 each month. Restrictions apply.

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Support to help you start and stay on RYBELSUS®

RYBELSUS® Connect offers support when and where you need it. Textb READY to 21848 to get started.

MORE INFO

aEligible, commercially insured patients only. For 3 mg dose, pay as little as $10 each month. Restrictions apply.

bMessage and data rates may apply. Check with your mobile service provider. Message frequency will be based on your selections. Text HELP to 21848 for help. Text STOP to 21848 to quit. See Terms and Conditions of Use.

Indication and Important Safety Information
READ MORE COLLAPSE

What is RYBELSUS®?

RYBELSUS® (semaglutide) tablets 7 mg or 14 mg is a prescription medicine used along with diet and exercise to improve blood sugar (glucose) in adults with type 2 diabetes.

  • RYBELSUS® is not recommended as the first choice of medicine for treating diabetes
  • It is not known if RYBELSUS® can be used in people who have had pancreatitis
  • RYBELSUS® is not for use in people with type 1 diabetes
  • It is not known if RYBELSUS® is safe and effective for use in children under 18 years of age
Scroll to Indication

Important Safety Information

What is the most important information I should know about RYBELSUS®?

RYBELSUS® may cause serious side effects, including:

  • Possible thyroid tumors, including cancer. Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rodents, RYBELSUS® and medicines that work like RYBELSUS® caused thyroid tumors, including thyroid cancer. It is not known if RYBELSUS® will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people

Do not use RYBELSUS® if:

  • you or any of your family have ever had MTC, or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
  • you have had a serious allergic reaction to semaglutide or any of the ingredients in RYBELSUS®. See symptoms of serious allergic reaction in "What are the possible side effects of RYBELSUS®?"

Before using RYBELSUS®, tell your healthcare provider if you have any other medical conditions, including if you:

  • have or have had problems with your pancreas or kidneys
  • have a history of vision problems related to your diabetes
  • are pregnant or plan to become pregnant. It is not known if RYBELSUS® will harm your unborn baby. You should stop using RYBELSUS® 2 months before you plan to become pregnant. Talk to your healthcare provider about the best way to control your blood sugar if you plan to become pregnant or while you are pregnant
  • are breastfeeding or plan to breastfeed. Breastfeeding is not recommended during treatment with RYBELSUS®

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. RYBELSUS® may affect the way some medicines work and some medicines may affect the way RYBELSUS® works.

How should I take RYBELSUS®?

  • Take RYBELSUS® exactly as your healthcare provider tells you to
  • Take RYBELSUS® by mouth on an empty stomach when you first wake up with a sip of plain water (no more than 4 ounces)
  • Do not split, crush, or chew. Swallow RYBELSUS® whole
  • After 30 minutes, you can eat, drink, or take other oral medicines
  • If you miss a dose of RYBELSUS®, skip the missed dose and go back to your regular schedule

What are the possible side effects of RYBELSUS®?

RYBELSUS® may cause serious side effects, including:

  • inflammation of your pancreas (pancreatitis). Stop using RYBELSUS® and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without vomiting. You may feel the pain from your abdomen to your back
  • changes in vision. Tell your healthcare provider if you have changes in vision during treatment with RYBELSUS®  
  • low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if you use RYBELSUS® with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin. Signs and symptoms of low blood sugar may include: dizziness or lightheadedness, blurred vision, anxiety, irritability or mood changes, sweating, slurred speech, hunger, confusion or drowsiness, shakiness, weakness, headache, fast heartbeat, and feeling jittery
  • kidney problems (kidney failure). In people who have kidney problems, diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems to get worse. It is important for you to drink fluids to help reduce your chance of dehydration
  • serious allergic reactions. Stop using RYBELSUS® and get medical help right away, if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue, or throat; problems breathing or swallowing; severe rash or itching; fainting or feeling dizzy; or very rapid heartbeat
  • gallbladder problems. Gallbladder problems have happened in some people who take RYBELSUS®. Tell your healthcare provider right away if you get symptoms of gallbladder problems, which may include: pain in your upper stomach (abdomen), yellowing of skin or eyes (jaundice), fever, and clay-colored stools

The most common side effects of RYBELSUS® may include nausea, stomach (abdominal) pain, diarrhea, decreased appetite, vomiting, and constipation. Nausea, vomiting, and diarrhea are most common when you first start RYBELSUS®.

Scroll to ISI

What is RYBELSUS®?

RYBELSUS® (semaglutide) tablets 7 mg or 14 mg is a prescription medicine used along with diet and exercise to improve blood sugar (glucose) in adults with type 2 diabetes.

  • RYBELSUS® is not recommended as the first choice of medicine for treating diabetes
  • It is not known if RYBELSUS® can be used in people who have had pancreatitis
  • RYBELSUS® is not for use in people with type 1 diabetes
  • It is not known if RYBELSUS® is safe and effective for use in children under 18 years of age

Please see Prescribing Information and Medication Guide for RYBELSUS®.

RYBELSUS® is a prescription medication.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

 

What is RYBELSUS®?

RYBELSUS® (semaglutide) tablets 7 mg or 14 mg is a prescription medicine used along with diet and exercise to improve blood sugar (glucose) in adults with type 2 diabetes.

  • RYBELSUS® is not recommended as the first choice of medicine for treating diabetes
  • It is not known if RYBELSUS® can be used in people who have had pancreatitis
  • RYBELSUS® is not for use in people with type 1 diabetes
  • It is not known if RYBELSUS® is safe and effective for use in children under 18 years of age

Important Safety Information

What is the most important information I should know about RYBELSUS®?

RYBELSUS® may cause serious side effects, including:

  • Possible thyroid tumors, including cancer. Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rodents, RYBELSUS® and medicines that work like RYBELSUS® caused thyroid tumors, including thyroid cancer. It is not known if RYBELSUS® will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people

Do not use RYBELSUS® if:

  • you or any of your family have ever had MTC, or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
  • you have had a serious allergic reaction to semaglutide or any of the ingredients in RYBELSUS®. See symptoms of serious allergic reaction in "What are the possible side effects of RYBELSUS®?"

Before using RYBELSUS®, tell your healthcare provider if you have any other medical conditions, including if you:

  • have or have had problems with your pancreas or kidneys
  • have a history of vision problems related to your diabetes
  • are pregnant or plan to become pregnant. It is not known if RYBELSUS® will harm your unborn baby. You should stop using RYBELSUS® 2 months before you plan to become pregnant. Talk to your healthcare provider about the best way to control your blood sugar if you plan to become pregnant or while you are pregnant
  • are breastfeeding or plan to breastfeed. Breastfeeding is not recommended during treatment with RYBELSUS®

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. RYBELSUS® may affect the way some medicines work and some medicines may affect the way RYBELSUS® works.

How should I take RYBELSUS®?

  • Take RYBELSUS® exactly as your healthcare provider tells you to
  • Take RYBELSUS® by mouth on an empty stomach when you first wake up with a sip of plain water (no more than 4 ounces)
  • Do not split, crush, or chew. Swallow RYBELSUS® whole
  • After 30 minutes, you can eat, drink, or take other oral medicines
  • If you miss a dose of RYBELSUS®, skip the missed dose and go back to your regular schedule

What are the possible side effects of RYBELSUS®?

RYBELSUS® may cause serious side effects, including:

  • inflammation of your pancreas (pancreatitis). Stop using RYBELSUS® and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without vomiting. You may feel the pain from your abdomen to your back
  • changes in vision. Tell your healthcare provider if you have changes in vision during treatment with RYBELSUS®  
  • low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if you use RYBELSUS® with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin. Signs and symptoms of low blood sugar may include: dizziness or lightheadedness, blurred vision, anxiety, irritability or mood changes, sweating, slurred speech, hunger, confusion or drowsiness, shakiness, weakness, headache, fast heartbeat, and feeling jittery
  • kidney problems (kidney failure). In people who have kidney problems, diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems to get worse. It is important for you to drink fluids to help reduce your chance of dehydration
  • serious allergic reactions. Stop using RYBELSUS® and get medical help right away, if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue, or throat; problems breathing or swallowing; severe rash or itching; fainting or feeling dizzy; or very rapid heartbeat
  • gallbladder problems. Gallbladder problems have happened in some people who take RYBELSUS®. Tell your healthcare provider right away if you get symptoms of gallbladder problems, which may include: pain in your upper stomach (abdomen), yellowing of skin or eyes (jaundice), fever, and clay-colored stools

The most common side effects of RYBELSUS® may include nausea, stomach (abdominal) pain, diarrhea, decreased appetite, vomiting, and constipation. Nausea, vomiting, and diarrhea are most common when you first start RYBELSUS®.

What is RYBELSUS®?

RYBELSUS® (semaglutide) tablets 7 mg or 14 mg is a prescription medicine used along with diet and exercise to improve blood sugar (glucose) in adults with type 2 diabetes.

  • RYBELSUS® is not recommended as the first choice of medicine for treating diabetes
  • It is not known if RYBELSUS® can be used in people who have had pancreatitis
  • RYBELSUS® is not for use in people with type 1 diabetes
  • It is not known if RYBELSUS® is safe and effective for use in children under 18 years of age

Please see Prescribing Information and Medication Guide for RYBELSUS®.

RYBELSUS® is a prescription medication.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

 

RYBELSUS® is a registered trademark of Novo Nordisk A/S.
Novo Nordisk is a registered trademark of Novo Nordisk A/S.
All other trademarks, registered or unregistered, are the property of their respective owners.
© 2023 Novo Nordisk   All rights reserved.   US23RYB00204   April 2023

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