What to Expect With RYBELSUS® (semaglutide) tablets
For RYBELSUS® to work as planned, take it as directed, every day
Improving your blood sugar is a very important part of managing your type 2 diabetes. RYBELSUS®, along with healthy eating and staying active, may help.
You'll start with a 3 mg dose of RYBELSUS® for 30 days. Your healthcare professional will prescribe a 7 mg dose to take after the first 30 days.

Learn more about dose changes, side effects, and support while taking RYBELSUS®.

Learn more about dose changes, side effects, and support while taking RYBELSUS®.
3 mg dose
The starting dose is 3 mg for the first 30 days to help your body get used to the medicine.
7 mg dose
After your 3 mg pills are finished, you will be prescribed the 7 mg dose to help lower blood sugar.
Remember to pick up your 7 mg prescription from your pharmacy before you are done with your 3 mg pills.
14 mg dose
After at least 30 days taking the 7 mg dose, your healthcare professional may prescribe the 14 mg dose if more blood sugar control is needed.
Make sure to follow up with your doctor after at least 30 days taking your 7 mg dose to see if you need more blood sugar control.
Why does my RYBELSUS® dose change?
- You take the 3 mg starting dose for 30 days to help your body get used to the medicine
- After your 3 mg pills are finished, you will be prescribed your 7 mg dose to help lower blood sugar
- After at least 30 days on the 7 mg dose, your healthcare professional may prescribe the 14 mg dose for greater blood sugar control
Common side effects of RYBELSUS®
There are possible side effects when taking RYBELSUS®. Always talk to your healthcare professional right away about any side effect that bothers you or doesn't go away.
The most common side effects of RYBELSUS® may include:
The most common side effects of RYBELSUS® may include:
Nausea
Vomiting
Diarrhea
Stomach (abdominal) pain
Decreased appetite
Constipation
Nausea
Diarrhea
Vomiting
Stomach (abdominal) pain
Decreased appetite
Constipation
Nausea
Vomiting
Diarrhea
Stomach (abdominal) pain
Decreased appetite
Constipation
Nausea
Diarrhea
Vomiting
Stomach (abdominal) pain
Decreased appetite
Constipation
Nausea
Diarrhea
Vomiting
Stomach (abdominal) pain
Decreased appetite
Constipation
Nausea, vomiting, and diarrhea are most common when first starting RYBELSUS® and when your dose increases.a
aIn studies, gastrointestinal side effects were more common in people taking RYBELSUS® than in people taking placebo, and people taking RYBELSUS® were more likely to stop treatment because of these side effects. Nausea, vomiting, and diarrhea may cause a loss of fluids (dehydration), which could cause existing kidney problems to get worse (including kidney failure).
If you experience any side effects while taking RYBELSUS®, please talk to your healthcare professional.
For a complete list of the possible side effects of RYBELSUS®, see the Prescribing Informationopens in a new tab and Medication Guideopens in a new tab.
For medical advice about side effects, talk with your healthcare professional. You may report side effects to the FDA at 1-800-FDA-1088.
Here are some general nausea tips that may be helpful:
Here are some general nausea tips that may be helpful:
Eat bland, low-fat foods, like crackers, toast, and rice
Eat foods that contain water, like soups and gelatin
Avoid fried, greasy, or sweet foods
Avoid lying down after you eat
Go outdoors for fresh air
Slowly eat smaller, more frequent meals
Drink clear or ice-cold drinks
Textb READY to 21848 to sign up for support
RYBELSUS® Connect can help you establish a routine with text message reminders and motivational messages.
bMessage and data rates may apply. Check with your mobile service provider. Message frequency will be based on your selections. Text HELP to 21848 for help. Text STOP to 21848 to quit. See Terms and Conditions of Useopens in a new tab.
Diabetes support when you need it
For one-on-one, live support from a Diabetes Health Coach, if you need it.
Call 1-833-ASK-A-CDE
(1-833-275-2233)
Monday – Friday, 9:00 AM – 6:00 PM ET
Get your A1C DOWN with RYBELSUS®
Once-daily RYBELSUS® is proven to significantly lower A1C.
Pay as little as $10 for up to a 3-month RYBELSUS®
prescriptiona
Check your insurance coverage and learn about ways to save.
aTo receive offer, 7 mg or 14 mg dose prescription must be for a 1-, 2-, or 3-month supply. For 3 mg dose, pay as little as $10 each month. Eligible, commercially insured patients with product coverage only. Maximum savings of $300 per 1‑month supply, $600 per 2‑month supply, or $900 per 3‑month supply. Eligibility and other restrictions applyopens in a new tab.
Support to help you start and stay on RYBELSUS®
RYBELSUS® Connect offers support when and where you need it. Textb READY to 21848 to get started.
aTo receive offer, 7 mg or 14 mg dose prescription must be for a 1-, 2-, or 3-month supply. For 3 mg dose, pay as little as $10 each month. Eligible, commercially insured patients with product coverage only. Maximum savings of $300 per 1‑month supply, $600 per 2‑month supply, or $900 per 3‑month supply. Eligibility and other restrictions applyopens in a new tab.
bMessage and data rates may apply. Check with your mobile service provider. Message frequency will be based on your selections. Text HELP to 21848 for help. Text STOP to 21848 to quit. See Terms and Conditions of Useopens in a new tab.
What is RYBELSUS®?
RYBELSUS® (semaglutide) tablets 7 mg or 14 mg is a prescription medicine used along with diet and exercise to improve blood sugar (glucose) in adults with type 2 diabetes.
- RYBELSUS® is not for use in people with type 1 diabetes
- It is not known if RYBELSUS® is safe and effective for use in children
Important Safety Information
What is the most important information I should know about RYBELSUS®?
RYBELSUS® may cause serious side effects, including:
- Possible thyroid tumors, including cancer. Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rodents, RYBELSUS® and medicines that work like RYBELSUS® caused thyroid tumors, including thyroid cancer. It is not known if RYBELSUS® will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people
Do not use RYBELSUS® if:
- you or any of your family have ever had MTC, or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
- you have had a serious allergic reaction to semaglutide or any of the ingredients in RYBELSUS®. See symptoms of serious allergic reaction in "What are the possible side effects of RYBELSUS®?"
Before using RYBELSUS®, tell your healthcare provider if you have any other medical conditions, including if you:
- have or have had problems with your pancreas or kidneys
- have a history of vision problems related to your diabetes
- are scheduled to have surgery or other procedures that use anesthesia or deep sleepiness (deep sedation)
- are pregnant or plan to become pregnant. It is not known if RYBELSUS® will harm your unborn baby. You should stop using RYBELSUS® 2 months before you plan to become pregnant
- are breastfeeding or plan to breastfeed. Breastfeeding is not recommended during treatment with RYBELSUS®
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. RYBELSUS® may affect the way some medicines work and some medicines may affect the way RYBELSUS® works.
How should I take RYBELSUS®?
- Take RYBELSUS® exactly as your healthcare provider tells you to
- Do not take more than 1 tablet each day
- Take RYBELSUS® by mouth on an empty stomach in the morning with a sip of plain water (no more than 4 ounces). Do not take RYBELSUS® with any other liquids besides water
- Do not split, crush, or chew. Swallow RYBELSUS® whole
- After 30 minutes, you can eat, drink, or take other oral medicines
- If you miss a dose of RYBELSUS®, skip the missed dose and go back to your regular schedule
What are the possible side effects of RYBELSUS®?
RYBELSUS® may cause serious side effects, including:
- inflammation of your pancreas (pancreatitis). Stop using RYBELSUS® and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without vomiting. You may feel the pain from your abdomen to your back
- changes in vision. Tell your healthcare provider if you have changes in vision during treatment with RYBELSUS®
- low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if you use RYBELSUS® with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin. Signs and symptoms of low blood sugar may include: dizziness or lightheadedness, blurred vision, anxiety, irritability or mood changes, sweating, slurred speech, hunger, confusion or drowsiness, shakiness, weakness, headache, fast heartbeat, and feeling jittery
- kidney problems (kidney failure). In people who have kidney problems, diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems to get worse. It is important for you to drink fluids to help reduce your chance of dehydration
- severe stomach problems. Stomach problems, sometimes severe, have been reported in people who use RYBELSUS®. Tell your healthcare provider if you have stomach problems that are severe or will not go away
- serious allergic reactions. Stop using RYBELSUS® and get medical help right away, if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue, or throat; problems breathing or swallowing; severe rash or itching; fainting or feeling dizzy; or very rapid heartbeat
- gallbladder problems. Gallbladder problems have happened in some people who take RYBELSUS®. Tell your healthcare provider right away if you get symptoms of gallbladder problems, which may include: pain in your upper stomach (abdomen), yellowing of skin or eyes (jaundice), fever, and clay-colored stools
- food or liquid getting into the lungs during surgery or other procedures that use anesthesia or deep sleepiness (deep sedation). RYBELSUS® may increase the chance of food getting into your lungs during surgery or other procedures. Tell all your healthcare providers that you are taking RYBELSUS® before you are scheduled to have surgery or other procedures
The most common side effects of RYBELSUS® may include nausea, stomach (abdominal) pain, diarrhea, decreased appetite, vomiting, and constipation. Nausea, vomiting, and diarrhea are most common when you first start RYBELSUS®.
Please see Prescribing Informationopens in a new tab and Medication Guideopens in a new tab for RYBELSUS®.
RYBELSUS® is a prescription medication.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatchopens in a new tab or call 1-800-FDA-1088.